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Title   Medulloblastoma/PNET에서의 p53 단백질 발현 양상에 관한 연구 ( Immunohistochemical Study on Expression of the p53 Pretein in Medulloblastoma/PNET )
Publicationinfo   1997 Jan; 029(05): 867-874.
Key_word   Medulloblastoma, Primitive neuroectodermal tumor, Immunohistochemical stain, p53
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Abstract   Purpose: The present study explores the expression rate of p53 mutation and the correlation between the expression of p53 protein and prognostic factors in medulloblastoma/ PNET (primitive neuroectodermal tumor). Materials and Methods: We studied retrospectively 24 patients with medulloblastoma/ PNET, who were admitted in Dong-A University Hospital, Pusan National University Hospital and Inje University Pusan Paik Hospital from 1988 to 1995. Detection of p53 mutations was made by immunohistochemical staining of p53 protein on paraffin- embedded tissues. The correlation between the expression of p53 protein and prognostic factors was evaluated by the Spearman correlation analysis. Results: p53 protein was expressed in 6 of 24 patients(25%). In 20 patients who could be evaluated for metastasis, 16 patients of M0, 1 patient of M1 and 3 patients of M2 were grouped by M stage, and the expression of p53 was detected in 1 of 16 M0 group(6.3%) and 3 of 3 M2 group(100%). p53 expression was significantly related to the M stage of medulloblastoma/PNET(r=0.73, p < 0.001). The detection of p53 was not significantly associated with T stage, cellular differentiation and the relapse rate of medulloblastoma/ PNET. Conclusion: The immunohistochemical detection rate of p53 protein in medulloblastoma/ PNET was 25%. The expression of p53 protein was significantly related to the M stage, with higher expression rate in M2 group of medulloblsatoma/PNET.
저 자   김은정(Eun Jung Kim),박상수(Sang Soo Park),이영호(Young Ho Lee),최안홍(An Hong Choi),나서희(Seo Hee Na),이순용(Soon Yong Lee),윤혜경(Hye Kyng Yoon),임영탁(Young Tak Lim),박도윤(Do Yoon Park),서강석(Kang Seok Seo)